Effect and mechanism of fisetin against the development of metabolic dysfunction-associated fatty liver disease
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-14 23:47
摘要：
Fisetin, a dietary flavonoid, shows promise in treating metabolic dysfunction-associated fatty liver disease (MAFLD) by improving glucose and lipid metabolism. In vivo studies demonstrated its ability to mitigate weight gain, enhance antioxidant capacity, and regulate key metabolic pathways in the liver. The research highlights Fisetin's potential as a therapeutic agent against MAFLD, supported by robust experimental data and significant gene expression changes. Further studies are needed to explore its clinical applications and safety profile.
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关键证据
Fisetin mitigated weight gain and improved blood glucose levels in mice.
RNA-seq analysis revealed significant gene expression changes in liver.
Fisetin activated the GSK-3β/Nrf2/HO-1 signaling pathway.
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AI评分总结
Fisetin, a dietary flavonoid, shows promise in treating metabolic dysfunction-associated fatty liver disease (MAFLD) by improving glucose and lipid metabolism. In vivo studies demonstrated its ability to mitigate weight gain, enhance antioxidant capacity, and regulate key metabolic pathways in the liver. The research highlights Fisetin's potential as a therapeutic agent against MAFLD, supported by robust experimental data and significant gene expression changes. Further studies are needed to explore its clinical applications and safety profile.