Protective effect of tanshinone IIA against Listeria monocytogenes infection in vitro and in vivo
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-15 23:35
摘要：
Tan IIA, a bioactive compound from traditional Chinese medicine, has been shown to protect against Listeria monocytogenes infection by inhibiting the virulence factor Listeriolysin O (LLO). In vitro and in vivo studies demonstrated its ability to reduce cytotoxicity and bacterial loads, while improving survival rates in infected mice. This research highlights the potential of Tan IIA as an alternative therapeutic approach to combat antibiotic-resistant Listeria infections.
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关键证据
Tan IIA significantly inhibited the pore-forming activity of LLO.
In vivo studies showed a 26.7% increase in survival rates of infected mice.
Tan IIA reduced bacterial loads and alleviated tissue damage in infected mice.
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AI评分总结
Tan IIA, a bioactive compound from traditional Chinese medicine, has been shown to protect against Listeria monocytogenes infection by inhibiting the virulence factor Listeriolysin O (LLO). In vitro and in vivo studies demonstrated its ability to reduce cytotoxicity and bacterial loads, while improving survival rates in infected mice. This research highlights the potential of Tan IIA as an alternative therapeutic approach to combat antibiotic-resistant Listeria infections.