Integrating in-silico and experimental validation approaches to unveil the therapeutic mechanism of naringenin against breast cancer
8.5
来源：
Nature
关键字：
computational pathology
发布时间：
2025-10-15 23:38
摘要：
This study investigates the therapeutic potential of Naringenin against breast cancer, utilizing an integrative approach that combines network pharmacology and experimental validation. Findings indicate that Naringenin effectively inhibits breast cancer cell proliferation and induces apoptosis, targeting key proteins like SRC, PIK3CA, BCL2, and ESR1. The research underscores the importance of Naringenin in developing novel cancer therapies and highlights its mechanisms of action through significant signaling pathways.
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1.0分
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0.5分
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1.5分
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2.5分
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关键证据
Naringenin shows antiproliferative effects in breast cancer cells.
Integration of network pharmacology and experimental validation provides mechanistic insights.
Naringenin targets key oncogenic proteins such as SRC and PIK3CA.
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AI评分总结
This study investigates the therapeutic potential of Naringenin against breast cancer, utilizing an integrative approach that combines network pharmacology and experimental validation. Findings indicate that Naringenin effectively inhibits breast cancer cell proliferation and induces apoptosis, targeting key proteins like SRC, PIK3CA, BCL2, and ESR1. The research underscores the importance of Naringenin in developing novel cancer therapies and highlights its mechanisms of action through significant signaling pathways.