NR4A1 expression aberrations contribute to radiotherapy resistance in gastric cancer
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-18 03:44
摘要：
The study investigates the role of NR4A1 in gastric cancer (GC) radioresistance, revealing that its downregulation contributes to treatment failure. High-throughput sequencing identified NR4A1's expression abnormalities in radioresistant GC cells. Overexpression of NR4A1 enhanced radiation sensitivity and inhibited tumor growth and metastasis in animal models. These findings suggest NR4A1 as a potential therapeutic target to overcome radiotherapy resistance in GC, emphasizing its significance in improving patient outcomes.
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关键证据
NR4A1 expression was significantly reduced in radioresistant cells.
Overexpressing NR4A1 increased sensitivity to radiation.
NR4A1 plays a crucial role in enhancing radiation sensitivity.
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AI评分总结
The study investigates the role of NR4A1 in gastric cancer (GC) radioresistance, revealing that its downregulation contributes to treatment failure. High-throughput sequencing identified NR4A1's expression abnormalities in radioresistant GC cells. Overexpression of NR4A1 enhanced radiation sensitivity and inhibited tumor growth and metastasis in animal models. These findings suggest NR4A1 as a potential therapeutic target to overcome radiotherapy resistance in GC, emphasizing its significance in improving patient outcomes.