Eosinophil-derived interleukin-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthma
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-20 23:42
摘要：
IL-24, secreted by eosinophils, exacerbates airway inflammation and remodeling in asthma. Its deficiency improves lung function and reduces eosinophilia in mouse models. Elevated IL-24 levels in asthma patients suggest its potential as a biomarker and therapeutic target. The study highlights IL-24's role in modulating immune responses and epithelial integrity, indicating its relevance in asthma pathogenesis.
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关键证据
IL-24 deficiency alleviates airway inflammation and remodeling.
IL-24 is primarily secreted by eosinophils in asthma models.
Elevated IL-24 levels correlate with asthma severity in patients.
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AI评分总结
IL-24, secreted by eosinophils, exacerbates airway inflammation and remodeling in asthma. Its deficiency improves lung function and reduces eosinophilia in mouse models. Elevated IL-24 levels in asthma patients suggest its potential as a biomarker and therapeutic target. The study highlights IL-24's role in modulating immune responses and epithelial integrity, indicating its relevance in asthma pathogenesis.