What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain
6.5
来源：
Nature
关键字：
neural coding
发布时间：
2025-10-21 15:37
摘要：
Chronic low back pain (LBP) is a significant global health issue, primarily linked to intervertebral disc degeneration (IVDD). This review explores the complex mechanisms behind discogenic LBP, emphasizing the need for innovative diagnostic and therapeutic strategies. It highlights the multifactorial nature of LBP, including biochemical, mechanical, and inflammatory factors, and discusses current limitations in treatment approaches that focus mainly on symptom management rather than addressing underlying causes. The article calls for further research to develop targeted therapies and improve patient outcomes.
原文：
查看原文
价值分投票
评分标准
新闻价值分采用0-10分制，综合考虑新闻的真实性、重要性、时效性、影响力等多个维度。
评分越高，表示该新闻的价值越大，越值得关注。
价值维度分析
domain_focus
1.0
business_impact
1.0
scientific_rigor
1.5
timeliness_innovation
1.5
investment_perspective
0.5
market_value_relevance
1.0
team_institution_background
0.0
technical_barrier_competition
0.0
关键证据
Chronic lower back pain (LBP) is the leading cause of disability worldwide.
Research has historically focused on intervertebral disc degeneration (IVDD) rather than LBP itself.
The review identifies key advancements and methodologies relevant to research and treatment approaches.
真实性检查
否
AI评分总结
Chronic low back pain (LBP) is a significant global health issue, primarily linked to intervertebral disc degeneration (IVDD). This review explores the complex mechanisms behind discogenic LBP, emphasizing the need for innovative diagnostic and therapeutic strategies. It highlights the multifactorial nature of LBP, including biochemical, mechanical, and inflammatory factors, and discusses current limitations in treatment approaches that focus mainly on symptom management rather than addressing underlying causes. The article calls for further research to develop targeted therapies and improve patient outcomes.