Tacrolimus modulates the PI3K AKT mTOR pathway in retinal epithelial cells under inflammatory stress
7.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-21 23:37
摘要：
Tacrolimus demonstrates the ability to modulate the PI3K/AKT/mTOR signaling pathway in human retinal pigment epithelial cells under inflammatory stress. The study identifies 38 differentially expressed genes associated with this pathway, indicating tacrolimus's potential as a therapeutic agent for proliferative vitreoretinopathy (PVR). The findings suggest that tacrolimus may help control fibrotic remodeling in retinal diseases, highlighting its relevance in biotechnology and medical research.
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关键证据
Tacrolimus modulates the PI3K/AKT/mTOR signaling pathway in H-RPE cells.
38 PI3K/AKT/mTOR-associated mRNAs showed significant differential expression.
The study supports the therapeutic potential of tacrolimus in retinal fibrosis.
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AI评分总结
Tacrolimus demonstrates the ability to modulate the PI3K/AKT/mTOR signaling pathway in human retinal pigment epithelial cells under inflammatory stress. The study identifies 38 differentially expressed genes associated with this pathway, indicating tacrolimus's potential as a therapeutic agent for proliferative vitreoretinopathy (PVR). The findings suggest that tacrolimus may help control fibrotic remodeling in retinal diseases, highlighting its relevance in biotechnology and medical research.