Crocetin curbs radiation induced intestinal injury by blocking KAT2A/NLRP3 succinylation
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-21 23:51
摘要：
Crocetin, a natural compound, has been shown to protect against radiation-induced intestinal injury by inhibiting KAT2A-mediated succinylation of NLRP3. This study provides evidence that crocetin enhances intestinal cell viability and reduces pyroptosis in irradiated models, suggesting its potential as a therapeutic agent in oncology, particularly for mitigating side effects of radiotherapy.
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domain_focus
1.0
business_impact
0.5
scientific_rigor
1.5
timeliness_innovation
1.5
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2.5
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1.0
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0.5
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关键证据
Crocetin ameliorated IR-induced intestinal injury in vivo.
KAT2A-mediated succinylation of NLRP3 was identified as a mechanism.
Crocetin's effects were supported by both in vivo and in vitro data.
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AI评分总结
Crocetin, a natural compound, has been shown to protect against radiation-induced intestinal injury by inhibiting KAT2A-mediated succinylation of NLRP3. This study provides evidence that crocetin enhances intestinal cell viability and reduces pyroptosis in irradiated models, suggesting its potential as a therapeutic agent in oncology, particularly for mitigating side effects of radiotherapy.