Genistein enhances anti-PD-1 efficacy in melanoma by suppressing regulatory T cell differentiation and activity
9.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-22 23:42
摘要：
Genistein, a natural isoflavonoid, enhances the efficacy of anti-PD-1 therapy in melanoma by suppressing regulatory T cell (Treg) differentiation and activity. This study demonstrates that genistein not only reduces Treg populations but also increases CD8+ T cell infiltration, leading to improved antitumor responses. The underlying mechanism involves the inhibition of the PI3K/AKT signaling pathway, suggesting that genistein could serve as a promising adjuvant in cancer immunotherapy.
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关键证据
Genistein enhances the antitumor effect of anti-PD-1 therapy by impairing the immunosuppressive function and differentiation of Tregs.
Mechanistic investigations revealed that genistein impairs Treg differentiation by suppressing the PI3K/AKT signaling pathway.
The combination of genistein and anti-PD-1 significantly amplified immune effects, reshaping the immune cell composition.
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AI评分总结
Genistein, a natural isoflavonoid, enhances the efficacy of anti-PD-1 therapy in melanoma by suppressing regulatory T cell (Treg) differentiation and activity. This study demonstrates that genistein not only reduces Treg populations but also increases CD8+ T cell infiltration, leading to improved antitumor responses. The underlying mechanism involves the inhibition of the PI3K/AKT signaling pathway, suggesting that genistein could serve as a promising adjuvant in cancer immunotherapy.