LC/ESI-MS/MS phytochemical profiling and apoptotic effect of Haloxylon scoparium leaf extract on hepatocellular carcinoma
9.5
来源：
Nature
关键字：
computational pathology
发布时间：
2025-10-24 03:38
摘要：
H. scoparium leaf extract exhibits significant anticancer effects against hepatocellular carcinoma (HCC) by modulating apoptotic pathways. The study identifies 27 phytochemical compounds through LC/ESI-MS/MS analysis, highlighting flavonoids like quercetin and isorhamnetin as key players. In vivo experiments demonstrate improved survival rates and liver function in treated mice, suggesting its potential as a therapeutic agent for HCC. The findings support further exploration of H. scoparium for its anticancer properties and therapeutic applications.
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关键证据
H. scoparium extract shows significant in vivo anticancer activity against HCC.
Phytochemical profiling identified 27 compounds, including flavonoids with strong binding affinities to cancer-related proteins.
Molecular docking results indicate potential multi-target effects of H. scoparium compounds.
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AI评分总结
H. scoparium leaf extract exhibits significant anticancer effects against hepatocellular carcinoma (HCC) by modulating apoptotic pathways. The study identifies 27 phytochemical compounds through LC/ESI-MS/MS analysis, highlighting flavonoids like quercetin and isorhamnetin as key players. In vivo experiments demonstrate improved survival rates and liver function in treated mice, suggesting its potential as a therapeutic agent for HCC. The findings support further exploration of H. scoparium for its anticancer properties and therapeutic applications.