Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-26 03:31
摘要：
This study investigates the rapid antidepressant effects of single-bout exercise, revealing that adiponectin signaling in ACC-glutamatergic neurons mediates these effects. The findings suggest that exercise increases adiponectin levels, which activate APPL1 nuclear translocation, leading to enhanced synaptic protein expression and mood improvement. This research highlights the potential for developing rapid-acting antidepressant therapies based on exercise-induced mechanisms.
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关键证据
Single-bout exercise significantly reduces total mood disturbance.
ACC-glutamatergic neurons are activated by exercise, mediating rapid antidepressant effects.
Adiponectin levels correlate with mood improvements post-exercise.
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AI评分总结
This study investigates the rapid antidepressant effects of single-bout exercise, revealing that adiponectin signaling in ACC-glutamatergic neurons mediates these effects. The findings suggest that exercise increases adiponectin levels, which activate APPL1 nuclear translocation, leading to enhanced synaptic protein expression and mood improvement. This research highlights the potential for developing rapid-acting antidepressant therapies based on exercise-induced mechanisms.