Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-28 03:36
摘要：
Cucurbitacin B (CuB) exhibits significant anti-tumor properties against glioblastoma (GBM) by inducing apoptosis through the STAT3/ROS/endoplasmic reticulum stress pathway. The study introduces M@CuB-Lips, a novel formulation enhancing targeted delivery to brain tumors, demonstrating substantial tumor inhibition in vivo. CuB's mechanism involves inhibiting STAT3 phosphorylation, elevating ROS levels, and activating ER stress, making it a promising candidate for GBM therapy. The findings highlight CuB's potential as a low-toxicity treatment option, addressing critical challenges in GBM management.
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关键证据
CuB induces apoptosis in GBM cells via the STAT3/ROS/ER stress pathway.
M@CuB-Lips enhances targeted delivery to brain tumors.
CuB shows significant tumor inhibition in vivo with low toxicity.
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AI评分总结
Cucurbitacin B (CuB) exhibits significant anti-tumor properties against glioblastoma (GBM) by inducing apoptosis through the STAT3/ROS/endoplasmic reticulum stress pathway. The study introduces M@CuB-Lips, a novel formulation enhancing targeted delivery to brain tumors, demonstrating substantial tumor inhibition in vivo. CuB's mechanism involves inhibiting STAT3 phosphorylation, elevating ROS levels, and activating ER stress, making it a promising candidate for GBM therapy. The findings highlight CuB's potential as a low-toxicity treatment option, addressing critical challenges in GBM management.