Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents
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来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-28 03:38
摘要：
Capsinoids, a class of non-pungent TRPV1 agonists, have been shown to induce mild hypothermia in conscious mice, presenting a novel pharmacological approach for therapeutic hypothermia in ischemic stroke. This study highlights the potential of capsinoids to activate heat defense mechanisms while suppressing cold defense responses, thereby improving the efficacy of hypothermia protocols. The findings suggest significant implications for enhancing neuroprotection in stroke patients, warranting further exploration in clinical settings.
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关键证据
Capsinoids induce a TRPV1-dependent drop in core body temperature.
Capsinoid-induced hypothermia is neuroprotective in an experimental model of ischemic stroke.
The study provides proof-of-principle for capsinoids as a new therapeutic approach.
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AI评分总结
Capsinoids, a class of non-pungent TRPV1 agonists, have been shown to induce mild hypothermia in conscious mice, presenting a novel pharmacological approach for therapeutic hypothermia in ischemic stroke. This study highlights the potential of capsinoids to activate heat defense mechanisms while suppressing cold defense responses, thereby improving the efficacy of hypothermia protocols. The findings suggest significant implications for enhancing neuroprotection in stroke patients, warranting further exploration in clinical settings.