Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways
10.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-28 07:36
摘要：
Amlodipine, a calcium channel blocker, exhibits significant inhibitory effects on glioma stem cells (GSCs) by degrading EGFR and down-regulating pro-survival pathways. The study reveals that amlodipine induces apoptosis, reduces cell viability, and suppresses self-renewal and invasiveness of GSCs. Mechanistically, amlodipine triggers EGFR internalization via lipid raft-mediated endocytosis, leading to lysosomal degradation. These findings highlight amlodipine's potential as a repurposed therapeutic agent against glioblastoma, warranting further clinical investigation.
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关键证据
Amlodipine exerts multifaceted inhibitory effects on GSCs.
The study suggests amlodipine has novel potential as a therapeutic agent targeting GSCs.
Amlodipine enhances EGFR degradation through activating endolysosomal pathway.
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AI评分总结
Amlodipine, a calcium channel blocker, exhibits significant inhibitory effects on glioma stem cells (GSCs) by degrading EGFR and down-regulating pro-survival pathways. The study reveals that amlodipine induces apoptosis, reduces cell viability, and suppresses self-renewal and invasiveness of GSCs. Mechanistically, amlodipine triggers EGFR internalization via lipid raft-mediated endocytosis, leading to lysosomal degradation. These findings highlight amlodipine's potential as a repurposed therapeutic agent against glioblastoma, warranting further clinical investigation.