Thiorphan reprograms neurons to promote functional recovery after spinal cord injury
9.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-30 03:52
摘要：
Thiorphan, identified through an in silico screening process, demonstrates significant potential for enhancing neuronal regeneration and functional recovery after spinal cord injury. In vitro studies showed a 1.8-fold increase in neurite outgrowth, while in vivo tests in rats indicated marked improvements in forelimb function when combined with neural stem cell grafts. The drug's efficacy was further validated in cultures of human and monkey cortical neurons, suggesting a promising pathway for clinical translation in treating spinal cord injuries.
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关键证据
Thiorphan increased neurite outgrowth by 1.8-fold in vitro.
Significant improvements in forelimb function were observed in rats treated with thiorphan.
Thiorphan's effects were confirmed in cultures from human and monkey neurons.
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AI评分总结
Thiorphan, identified through an in silico screening process, demonstrates significant potential for enhancing neuronal regeneration and functional recovery after spinal cord injury. In vitro studies showed a 1.8-fold increase in neurite outgrowth, while in vivo tests in rats indicated marked improvements in forelimb function when combined with neural stem cell grafts. The drug's efficacy was further validated in cultures of human and monkey cortical neurons, suggesting a promising pathway for clinical translation in treating spinal cord injuries.