Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathway
9.2
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-31 03:36
摘要：
Rutin has been shown to mitigate sevoflurane-induced neurotoxicity by reducing cognitive dysfunction and synaptic impairment in neonatal mice. The study highlights rutin's ability to inhibit microglial activation and phagocytosis through the complement pathway, suggesting its potential as a therapeutic agent for preventing developmental neurotoxicity associated with anesthesia. These findings underscore the importance of exploring natural compounds like rutin in neuroprotective strategies.
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关键证据
Rutin effectively alleviated cognitive dysfunction and synaptic impairment in sevoflurane-treated mice.
Rutin treatment decreased microglial activation and phagocytic properties.
Rutin inhibited complement-dependent microglial synapse phagocytosis.
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AI评分总结
Rutin has been shown to mitigate sevoflurane-induced neurotoxicity by reducing cognitive dysfunction and synaptic impairment in neonatal mice. The study highlights rutin's ability to inhibit microglial activation and phagocytosis through the complement pathway, suggesting its potential as a therapeutic agent for preventing developmental neurotoxicity associated with anesthesia. These findings underscore the importance of exploring natural compounds like rutin in neuroprotective strategies.