Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice
6.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-31 07:45
摘要：
This research investigates the dynamic nature of KRAB-zinc finger protein (KZFP) gene clusters in mice, revealing their significant role in genetic heterogeneity driven by endogenous retroviruses (ERVs). The study employs advanced sequencing technologies to analyze KZFP gene clusters, demonstrating how ERV integrations promote the emergence of new KZFPs. The findings suggest a model of coevolution between KZFPs and ERVs, highlighting the potential for these gene clusters to contribute to genetic diversity and regulatory networks in mammals.
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关键证据
The study presents a detailed comparative analysis of young KZFP gene clusters in the mouse lineage.
It uncovers mechanisms of ERV-driven genetic heterogeneity.
The findings suggest a model for the coevolution of KZFPs and ERVs.
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AI评分总结
This research investigates the dynamic nature of KRAB-zinc finger protein (KZFP) gene clusters in mice, revealing their significant role in genetic heterogeneity driven by endogenous retroviruses (ERVs). The study employs advanced sequencing technologies to analyze KZFP gene clusters, demonstrating how ERV integrations promote the emergence of new KZFPs. The findings suggest a model of coevolution between KZFPs and ERVs, highlighting the potential for these gene clusters to contribute to genetic diversity and regulatory networks in mammals.