Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens
7.4
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-01 03:37
摘要：
H2S exhibits significant antimicrobial effects against nail pathogens, particularly dermatophytes, which are challenging to treat with conventional antifungals. The study identifies novel mechanisms of action, including the inhibition of cytochrome C oxidase and the generation of reactive oxygen species, suggesting that H2S could serve as an innovative topical treatment for onychomycosis. The findings highlight the potential for H2S to penetrate the nail plate effectively, addressing a critical barrier in current treatment options.
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关键证据
H2S has potent activity against causative agents of nail infections, including fungi and bacteria.
Transcriptomic analysis revealed a stress response, indicating efforts to reduce oxidative stress.
H2S inhibits cytochrome C oxidase, leading to increased reactive oxygen species.
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AI评分总结
H2S exhibits significant antimicrobial effects against nail pathogens, particularly dermatophytes, which are challenging to treat with conventional antifungals. The study identifies novel mechanisms of action, including the inhibition of cytochrome C oxidase and the generation of reactive oxygen species, suggesting that H2S could serve as an innovative topical treatment for onychomycosis. The findings highlight the potential for H2S to penetrate the nail plate effectively, addressing a critical barrier in current treatment options.