Irisin inhibits dopaminergic neuron lactate metabolism and repairs mitochondrial function to alleviate Parkinson’s disease by activating SIRT1 signaling pathway
8.4
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-01 07:37
摘要：
Irisin demonstrates significant neuroprotective effects in a Parkinson's disease mouse model by improving motor function and promoting dopaminergic neuron survival. The study reveals that irisin inhibits lactate metabolism and restores mitochondrial function through activation of the SIRT1 signaling pathway. These findings suggest that irisin could be a promising therapeutic candidate for Parkinson's disease, warranting further investigation into its mechanisms and potential clinical applications.
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关键证据
Irisin treatment improved motor function and promoted dopaminergic neuron survival.
Irisin inhibited lactate metabolism and restored mitochondrial function.
Activation of the SIRT1 pathway was identified as a core therapeutic target.
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AI评分总结
Irisin demonstrates significant neuroprotective effects in a Parkinson's disease mouse model by improving motor function and promoting dopaminergic neuron survival. The study reveals that irisin inhibits lactate metabolism and restores mitochondrial function through activation of the SIRT1 signaling pathway. These findings suggest that irisin could be a promising therapeutic candidate for Parkinson's disease, warranting further investigation into its mechanisms and potential clinical applications.