Understanding the molecular basis of mesenchymal stem cell stemness: implications for clinical applications
7.5
来源：
Nature
关键字：
siRNA
发布时间：
2025-11-03 23:55
摘要：
The review discusses the molecular mechanisms that govern the stemness of human mesenchymal stem cells (MSCs), which are critical for their therapeutic applications in regenerative medicine. It highlights the role of various genetic factors and transcriptional regulators in maintaining MSC properties, emphasizing the need for a comprehensive understanding of these mechanisms to enhance clinical outcomes and develop effective MSC-based therapies.
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关键证据
Human mesenchymal stem cells (MSCs) have been studied in over 1500 clinical trials to treat over 30 diseases.
Emerging evidence shows that a variety of genetic factors delicately regulate MSC self-renewal and differentiation.
Understanding the molecular basis of MSC stemness enhances clinical applications and provides insights for improving MSC-based therapies.
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AI评分总结
The review discusses the molecular mechanisms that govern the stemness of human mesenchymal stem cells (MSCs), which are critical for their therapeutic applications in regenerative medicine. It highlights the role of various genetic factors and transcriptional regulators in maintaining MSC properties, emphasizing the need for a comprehensive understanding of these mechanisms to enhance clinical outcomes and develop effective MSC-based therapies.