Astragali Radix-Carthami Flos alleviate brain-heart injury after cerebral ischemia/reperfusion via regulating TSPO signaling
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-04 03:47
摘要：
Astragali Radix-Carthami Flos (ARCF) has shown promise in alleviating brain-heart injury following cerebral ischemia/reperfusion (CI/R) by regulating TSPO signaling. In a rat model, ARCF treatment improved neurological function and cardiac health, suggesting its potential as a therapeutic intervention for stroke-related complications. The study utilized transcriptomic analysis to identify key pathogenic mechanisms, highlighting oxidative phosphorylation and reactive oxygen species (ROS) production. TSPO emerged as a central target, indicating that ARCF may offer a novel approach to managing neurocardiac complications.
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关键证据
ARCF management mitigated CI/R-induced brain-heart injury, as evidenced by improved neurological function.
Transcriptomic analysis identified oxidative phosphorylation and ROS production as key pathogenic mechanisms.
TSPO was identified as a central target for ARCF's protective effects against brain-heart injury.
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AI评分总结
Astragali Radix-Carthami Flos (ARCF) has shown promise in alleviating brain-heart injury following cerebral ischemia/reperfusion (CI/R) by regulating TSPO signaling. In a rat model, ARCF treatment improved neurological function and cardiac health, suggesting its potential as a therapeutic intervention for stroke-related complications. The study utilized transcriptomic analysis to identify key pathogenic mechanisms, highlighting oxidative phosphorylation and reactive oxygen species (ROS) production. TSPO emerged as a central target, indicating that ARCF may offer a novel approach to managing neurocardiac complications.