The therapeutic potential of Zuogui Wan in oligoasthenozoospermia: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation
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来源：
Nature
关键字：
AI medical imaging
发布时间：
2025-11-05 07:48
摘要：
The study investigates the therapeutic potential of Zuogui Wan (ZGW) in treating oligoasthenozoospermia (OAS) using network pharmacology and experimental validation. ZGW enhances sperm quality and reduces apoptosis in a rat model, with key components identified through molecular docking. The findings suggest that ZGW operates through multiple signaling pathways, including PI3K-AKT and MAPK, highlighting its potential as a viable treatment for male infertility and its relevance in traditional Chinese medicine.
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domain_focus
1.0分+1.0分
business_impact
0.5分+0.5分
scientific_rigor
1.5分+1.5分
timeliness_innovation
1.5分+1.5分
investment_perspective
2.5分+2.5分
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关键证据
ZGW significantly improves testicular structure and sperm quality in OAS model rats.
Network pharmacology identifies 182 potential targets related to OAS.
Core components like Cyasterone show strong binding affinity to key proteins.
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AI评分总结
The study investigates the therapeutic potential of Zuogui Wan (ZGW) in treating oligoasthenozoospermia (OAS) using network pharmacology and experimental validation. ZGW enhances sperm quality and reduces apoptosis in a rat model, with key components identified through molecular docking. The findings suggest that ZGW operates through multiple signaling pathways, including PI3K-AKT and MAPK, highlighting its potential as a viable treatment for male infertility and its relevance in traditional Chinese medicine.