Unfreezing structural biology for drug discovery
6.0
来源：
Nature
关键字：
AI drug discovery
发布时间：
2025-11-05 23:58
摘要：
Recent advancements in structural biology are transforming drug discovery, particularly through the study of temperature-sensitive structural phenomena. By utilizing cryo-cooling techniques and exploring hidden conformational states, researchers are enhancing ligand discovery methods. These findings underscore the importance of conducting structural studies at elevated temperatures, which align more closely with biological conditions, thereby improving the accuracy of drug design and discovery processes.
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关键证据
The advent of cryo-cooling crystals in crystallography greatly accelerated the ease and accessibility of structural data.
Leveraging information on rare, hidden conformational states informs ligand discovery via molecular docking.
This study demonstrates that the impact of temperature on structure cascades to the performance of computational drug discovery approaches.
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AI评分总结
Recent advancements in structural biology are transforming drug discovery, particularly through the study of temperature-sensitive structural phenomena. By utilizing cryo-cooling techniques and exploring hidden conformational states, researchers are enhancing ligand discovery methods. These findings underscore the importance of conducting structural studies at elevated temperatures, which align more closely with biological conditions, thereby improving the accuracy of drug design and discovery processes.