Research progress on the role and mechanisms of ferroptosis in diabetic wound repair
7.5
来源：
Nature
关键字：
circRNA
发布时间：
2025-11-08 03:45
摘要：
Ferroptosis, a regulated form of cell death, significantly impacts the healing of diabetic wounds, which are often characterized by delayed recovery and high infection rates. This review discusses the mechanisms by which ferroptosis affects various cell types involved in wound repair, including macrophages, fibroblasts, endothelial cells, and keratinocytes. It also highlights the therapeutic potential of targeting ferroptosis to enhance healing outcomes, emphasizing the need for innovative strategies in managing diabetic wounds.
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关键证据
Ferroptosis is linked to impaired wound healing in diabetic patients.
Therapeutic strategies targeting ferroptosis show promise in improving healing.
The article provides a comprehensive review of the mechanisms involved.
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AI评分总结
Ferroptosis, a regulated form of cell death, significantly impacts the healing of diabetic wounds, which are often characterized by delayed recovery and high infection rates. This review discusses the mechanisms by which ferroptosis affects various cell types involved in wound repair, including macrophages, fibroblasts, endothelial cells, and keratinocytes. It also highlights the therapeutic potential of targeting ferroptosis to enhance healing outcomes, emphasizing the need for innovative strategies in managing diabetic wounds.