Impaired natural killer cell migration in HIV-infected individuals is caused by TIGIT-mediated inhibition of HIF-1α-dependent glycolysis
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来源：
Nature
关键字：
mRNA
发布时间：
2025-11-08 03:49
摘要：
This study investigates the impaired migration of natural killer (NK) cells in HIV-infected individuals, revealing that TIGIT-mediated inhibition of HIF-1α-dependent glycolysis is a key mechanism. The research highlights the correlation between NK cell migration and CD4+ T cell counts, suggesting potential therapeutic strategies targeting TIGIT to enhance NK cell function in HIV treatment.
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关键证据
NK cell migration is significantly impaired in HIV-infected individuals.
TIGIT expression inhibits glycolysis and migration of NK cells.
HIF-1α pathway is identified as a key regulator in this process.
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AI评分总结
This study investigates the impaired migration of natural killer (NK) cells in HIV-infected individuals, revealing that TIGIT-mediated inhibition of HIF-1α-dependent glycolysis is a key mechanism. The research highlights the correlation between NK cell migration and CD4+ T cell counts, suggesting potential therapeutic strategies targeting TIGIT to enhance NK cell function in HIV treatment.