Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes
7.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-11 03:44
摘要：
Lead nitrate (LN) induces significant metabolic reprogramming and proliferation in both rat and human hepatocytes, characterized by increased glycolysis and activation of the NRF2 pathway. This study highlights the direct effects of LN on hepatocytes, independent of non-parenchymal cells, and suggests that NRF2 activation is crucial for these metabolic changes. The findings provide insights into potential therapeutic strategies targeting metabolic pathways in hepatocellular carcinoma.
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关键证据
Lead nitrate induces cancer-like metabolic features in non-tumorigenic hepatocytes.
NRF2 plays a central role as a key driver of these cancer-like metabolic shifts.
The study demonstrates that LN directly drives both proliferation and metabolic reprogramming in hepatocytes.
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AI评分总结
Lead nitrate (LN) induces significant metabolic reprogramming and proliferation in both rat and human hepatocytes, characterized by increased glycolysis and activation of the NRF2 pathway. This study highlights the direct effects of LN on hepatocytes, independent of non-parenchymal cells, and suggests that NRF2 activation is crucial for these metabolic changes. The findings provide insights into potential therapeutic strategies targeting metabolic pathways in hepatocellular carcinoma.