TXNIP upregulation controls metabolism and cell cycle during androgen deprivation therapy in prostate cancer
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-11 03:46
摘要：
This study investigates the role of Thioredoxin-Interacting Protein (TXNIP) in prostate cancer, particularly during androgen deprivation therapy (ADT). It reveals that TXNIP regulates glucose metabolism and cell cycle progression, with higher levels correlating with better responses to ADT. The research highlights TXNIP's potential as a therapeutic target, suggesting that its recovery post-ADT is crucial for effective treatment outcomes. Findings are supported by both murine models and clinical samples, underscoring TXNIP's significance in prostate cancer management.
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关键证据
TXNIP expression is directly suppressed by androgens and diminishes during tumor initiation and progression.
TXNIP levels were significantly higher in ADT responders compared to non-responders.
TXNIP is identified as a critical regulator of cell cycle and glucose metabolism in prostate cancer.
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AI评分总结
This study investigates the role of Thioredoxin-Interacting Protein (TXNIP) in prostate cancer, particularly during androgen deprivation therapy (ADT). It reveals that TXNIP regulates glucose metabolism and cell cycle progression, with higher levels correlating with better responses to ADT. The research highlights TXNIP's potential as a therapeutic target, suggesting that its recovery post-ADT is crucial for effective treatment outcomes. Findings are supported by both murine models and clinical samples, underscoring TXNIP's significance in prostate cancer management.