CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-11 03:46
摘要：
CARMN loss has been shown to enhance the formation of VSMC-derived foam cells and accelerate atherosclerosis through the transcriptional downregulation of autophagy. This study elucidates the mechanisms by which CARMN regulates cholesterol efflux and highlights its potential as a therapeutic target in atherosclerosis management.
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关键证据
CARMN knockdown promotes VSMC-derived foam cell formation and atherosclerosis.
CARMN regulates autophagy via the AKT/ATG7 pathway.
CARMN is identified as a potential therapeutic target for atherosclerosis.
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AI评分总结
CARMN loss has been shown to enhance the formation of VSMC-derived foam cells and accelerate atherosclerosis through the transcriptional downregulation of autophagy. This study elucidates the mechanisms by which CARMN regulates cholesterol efflux and highlights its potential as a therapeutic target in atherosclerosis management.