Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune homeostasis
7.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-11 03:49
摘要：
PTIR1, a primate-specific splice variant of DDX58, functions as a negative regulator of innate immunity by modulating STAT1 and RIG-I signaling pathways. It is induced by viral infections and interferons, leading to reduced inflammatory responses and tissue damage in murine models of autoimmune hepatitis. The study highlights PTIR1's dual role in balancing antiviral defense and preventing excessive inflammation, suggesting its potential as a therapeutic target for autoimmune diseases.
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关键证据
PTIR1 suppresses STAT1-dependent type I and II interferon signaling.
PTIR1 overexpression reduces liver damage in autoimmune hepatitis models.
PTIR1 acts as a negative regulator of antiviral and inflammatory signaling.
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AI评分总结
PTIR1, a primate-specific splice variant of DDX58, functions as a negative regulator of innate immunity by modulating STAT1 and RIG-I signaling pathways. It is induced by viral infections and interferons, leading to reduced inflammatory responses and tissue damage in murine models of autoimmune hepatitis. The study highlights PTIR1's dual role in balancing antiviral defense and preventing excessive inflammation, suggesting its potential as a therapeutic target for autoimmune diseases.