Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges
8.4
来源：
Nature
关键字：
AI brain science
发布时间：
2025-11-12 23:32
摘要：
Human organoids, derived from stem cells, serve as advanced 3D platforms for drug discovery, closely mimicking human physiology. This review discusses their potential in modeling diseases, assessing drug efficacy and toxicity, and outlines methodologies for their generation and maintenance. It also addresses regulatory challenges and opportunities for broader adoption in drug discovery, highlighting the innovative nature of organoid technology in the biomedical field.
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关键证据
Organoids provide experimental models that more closely reflect human physiology.
Their ability to capture the complexity and heterogeneity of human tissues enables the study of disease mechanisms.
The review outlines current methodologies for generating and maintaining organoids.
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AI评分总结
Human organoids, derived from stem cells, serve as advanced 3D platforms for drug discovery, closely mimicking human physiology. This review discusses their potential in modeling diseases, assessing drug efficacy and toxicity, and outlines methodologies for their generation and maintenance. It also addresses regulatory challenges and opportunities for broader adoption in drug discovery, highlighting the innovative nature of organoid technology in the biomedical field.