Salvianolic acid A modulates α-Ketoisovaleric acid metabolism to inhibit human cartilage endplate cells apoptosis under mechanical tensile stress
8.3
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-12 23:37
摘要：
Salvianolic acid A (SAA) demonstrates protective effects on human cartilage endplate cells (CEPCs) under mechanical stress, enhancing cell viability and reducing apoptosis. The study employs non-targeted metabolomics to elucidate the metabolic changes induced by SAA, identifying its role in regulating α-ketoisovaleric acid metabolism and modulating miR-940 signaling pathways. These findings suggest SAA's potential as a therapeutic candidate for intervertebral disc degeneration, highlighting its relevance in medical research and traditional Chinese medicine.
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关键证据
SAA enhanced cell viability and reduced apoptosis of CEPCs under mechanical tensile loading.
Non-targeted metabolomics revealed that SAA modulated metabolic profiles associated with intervertebral disc degeneration.
SAA regulated α-ketoisovaleric acid and inhibited stress-loaded CEPCs apoptosis possibly by regulating miR-940 related signaling pathway.
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AI评分总结
Salvianolic acid A (SAA) demonstrates protective effects on human cartilage endplate cells (CEPCs) under mechanical stress, enhancing cell viability and reducing apoptosis. The study employs non-targeted metabolomics to elucidate the metabolic changes induced by SAA, identifying its role in regulating α-ketoisovaleric acid metabolism and modulating miR-940 signaling pathways. These findings suggest SAA's potential as a therapeutic candidate for intervertebral disc degeneration, highlighting its relevance in medical research and traditional Chinese medicine.