A Pseudomonas aeruginosa quorum-sensing metabolite manipulates macrophage ferroptosis through a methylation pathway
7.1
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-14 07:39
摘要：
Pseudomonas aeruginosa utilizes its quorum-sensing metabolite PQS to manipulate macrophage ferroptosis via the CNMT-TFR1 pathway. This study identifies CNMT as a crucial mediator, enhancing TFR1 expression and promoting iron influx, ultimately leading to ferroptosis. The findings suggest potential therapeutic targets for managing infections caused by P. aeruginosa, emphasizing the importance of understanding host-pathogen interactions.
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关键证据
PQS induces ferroptosis in macrophages through a methylation pathway.
CNMT identified as a key intracellular target of PQS.
PQS enhances TFR1 expression, leading to increased iron influx and ferroptosis.
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AI评分总结
Pseudomonas aeruginosa utilizes its quorum-sensing metabolite PQS to manipulate macrophage ferroptosis via the CNMT-TFR1 pathway. This study identifies CNMT as a crucial mediator, enhancing TFR1 expression and promoting iron influx, ultimately leading to ferroptosis. The findings suggest potential therapeutic targets for managing infections caused by P. aeruginosa, emphasizing the importance of understanding host-pathogen interactions.