Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-14 11:31
摘要：
Oligomeric cystatin C has been identified as a key player in enhancing the immunosuppressive activity of myeloid cells, which contributes to tumor progression. The study demonstrates that cystatin C interacts with inhibitory receptors LILRB2 and LILRB5, leading to T-cell suppression and promoting a more immunosuppressive tumor microenvironment. These findings suggest potential therapeutic strategies targeting the cystatin C-LILRB interaction to improve cancer treatment outcomes.
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关键证据
Oligomeric cystatin C enhances the immunosuppressive activity of myeloid cells.
Cystatin C interacts with LILRB2 and LILRB5, promoting tumor progression.
CST3 knockout mice exhibit reduced tumor growth, highlighting cystatin C's role in cancer.
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AI评分总结
Oligomeric cystatin C has been identified as a key player in enhancing the immunosuppressive activity of myeloid cells, which contributes to tumor progression. The study demonstrates that cystatin C interacts with inhibitory receptors LILRB2 and LILRB5, leading to T-cell suppression and promoting a more immunosuppressive tumor microenvironment. These findings suggest potential therapeutic strategies targeting the cystatin C-LILRB interaction to improve cancer treatment outcomes.