Comprehensive analysis of ALYREF gene expression and its correlation with immunotherapy efficacy and circulating tumor cells in bladder cancer
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-15 03:45
摘要：
ALYREF emerges as a significant biomarker in bladder cancer, correlating with aggressive tumor characteristics and improved responses to immunotherapy. This study integrates bioinformatics and clinical data, establishing ALYREF's role in patient stratification and treatment personalization. Elevated ALYREF levels indicate poorer survival outcomes while also predicting favorable responses to immune checkpoint inhibitors, suggesting its dual role in cancer progression and therapy efficacy.
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关键证据
ALYREF was significantly upregulated in BCa tissues, correlating with higher tumor grade and poorer overall survival.
High ALYREF expression was associated with a better response to immune checkpoint inhibitors.
ALYREF holds promise for refining patient stratification and personalizing BCa treatment.
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AI评分总结
ALYREF emerges as a significant biomarker in bladder cancer, correlating with aggressive tumor characteristics and improved responses to immunotherapy. This study integrates bioinformatics and clinical data, establishing ALYREF's role in patient stratification and treatment personalization. Elevated ALYREF levels indicate poorer survival outcomes while also predicting favorable responses to immune checkpoint inhibitors, suggesting its dual role in cancer progression and therapy efficacy.