Combination of THU/ALK-5i exhibits profound anti-MASH activity through suppression of lipogenesis and fibrogenesis
7.0
来源：
Nature
关键字：
de novo drug design
发布时间：
2025-11-15 03:59
摘要：
The study investigates the combination of tetrahydrocurcumin (THU) and EW-7197, an ALK-5 inhibitor, as a therapeutic strategy for metabolic dysfunction associated steatohepatitis (MASH). Results indicate that this combination effectively reduces liver fibrosis and improves metabolic health in both in vitro and in vivo models. The findings suggest a synergistic effect, making this combination a promising candidate for further development in treating liver diseases, highlighting its potential for early-stage investment in biopharmaceuticals.
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0.8分+0.8分
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1.5分+1.5分
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1.5分+1.5分
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2.5分+2.5分
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关键证据
Combination of THU and EW-7197 shows profound anti-MASH activity.
Significant reduction in liver fibrosis and improvement in metabolic parameters.
Study highlights the potential of THU as a therapeutic agent in MASH.
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AI评分总结
The study investigates the combination of tetrahydrocurcumin (THU) and EW-7197, an ALK-5 inhibitor, as a therapeutic strategy for metabolic dysfunction associated steatohepatitis (MASH). Results indicate that this combination effectively reduces liver fibrosis and improves metabolic health in both in vitro and in vivo models. The findings suggest a synergistic effect, making this combination a promising candidate for further development in treating liver diseases, highlighting its potential for early-stage investment in biopharmaceuticals.