Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut
7.4
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-17 23:33
摘要：
Fecal exfoliome sequencing (Foli-seq) is introduced as a novel method to profile fecal exfoliated RNAs, providing insights into immune dynamics in both healthy and inflamed guts. This technology shows promise in stratifying patients with inflammatory bowel disease and offers a noninvasive approach to studying gut health. The research, conducted at Columbia University, is supported by a patent application, indicating potential for commercialization and significant clinical impact.
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关键证据
Foli-seq demonstrates robust, accurate, sensitive and quantitative measurement of feRNAs.
Simultaneous exfoliome and microbiome profiling uncovers a dense host–microbe interaction network.
A patent application describing the Foli-seq technology has been filed by Columbia University.
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AI评分总结
Fecal exfoliome sequencing (Foli-seq) is introduced as a novel method to profile fecal exfoliated RNAs, providing insights into immune dynamics in both healthy and inflamed guts. This technology shows promise in stratifying patients with inflammatory bowel disease and offers a noninvasive approach to studying gut health. The research, conducted at Columbia University, is supported by a patent application, indicating potential for commercialization and significant clinical impact.