Chrysanthemum morifolium extract improves metabolic dysfunction-associated fatty liver disease by regulating lipid metabolism
8.0
来源：
Nature
关键字：
de novo drug design
发布时间：
2025-11-17 23:48
摘要：
Chrysanthemum morifolium extract has been shown to effectively improve metabolic dysfunction-associated fatty liver disease (MAFLD) by regulating lipid metabolism. The study highlights its ability to inhibit lipid synthesis via the SREBP-1c/FAS/ACCα pathway and enhance fatty acid oxidation through the PPARα/CPT-1 pathway. These findings suggest a promising direction for developing therapeutic agents for MAFLD, addressing a significant global health concern.
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关键证据
Chrysanthemum morifolium extract significantly reduces lipid accumulation in MAFLD models.
The study identifies the SREBP-1c/FAS/ACCα and PPARα/CPT-1 pathways as key regulators.
The extract shows potential for future drug development targeting MAFLD.
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AI评分总结
Chrysanthemum morifolium extract has been shown to effectively improve metabolic dysfunction-associated fatty liver disease (MAFLD) by regulating lipid metabolism. The study highlights its ability to inhibit lipid synthesis via the SREBP-1c/FAS/ACCα pathway and enhance fatty acid oxidation through the PPARα/CPT-1 pathway. These findings suggest a promising direction for developing therapeutic agents for MAFLD, addressing a significant global health concern.