Ketamine reduces microglial activation and brain monocyte infiltration and promotes peripheral regulatory immune cells, relieving lipopolysaccharide (LPS)-induced depressive-like behavior in mice
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-19 03:38
摘要：
Ketamine demonstrates significant antidepressant effects by reducing microglial activation and promoting regulatory immune cells in a murine model of depression induced by lipopolysaccharide (LPS). The study reveals that ketamine's anti-inflammatory properties may contribute to its rapid and sustained efficacy in treating Major Depressive Disorder (MDD), particularly in patients with inflammation. This research underscores the potential of ketamine as a novel therapeutic approach for MDD, highlighting its multifaceted mechanisms of action.
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关键证据
Ketamine administration alleviated despair and anhedonia in LPS-depressive-like mice.
Behavioral changes were accompanied by the reduction of Ly6G+ neutrophils and an increment of anti-inflammatory Ly6Clow/neg monocytes.
These findings highlight ketamine’s multifaceted mechanisms of action, underscoring its potential as a treatment for MDD.
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AI评分总结
Ketamine demonstrates significant antidepressant effects by reducing microglial activation and promoting regulatory immune cells in a murine model of depression induced by lipopolysaccharide (LPS). The study reveals that ketamine's anti-inflammatory properties may contribute to its rapid and sustained efficacy in treating Major Depressive Disorder (MDD), particularly in patients with inflammation. This research underscores the potential of ketamine as a novel therapeutic approach for MDD, highlighting its multifaceted mechanisms of action.