CircPSMA4 as a novel circular RNA enhances the proliferation migration invasion and metabolism of bladder cancer cells through the miR-767-3p/HIF1A pathway
8.0
来源：
Nature
关键字：
circRNA
发布时间：
2025-11-19 03:58
摘要：
CircPSMA4 is identified as a novel circular RNA that significantly enhances the proliferation, migration, invasion, and metabolic activities of bladder cancer cells through the miR-767-3p/HIF1A pathway. This research highlights the potential of circPSMA4 as a therapeutic target in bladder cancer, suggesting that interventions targeting this axis may improve treatment outcomes.
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关键证据
CircPSMA4 promotes proliferation, migration, invasion, and metabolism of bladder cancer cells.
Identified miR-767-3p as a downstream target of circPSMA4.
CircPSMA4 enhances glycolysis and mitochondrial respiration in bladder cancer cells.
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AI评分总结
CircPSMA4 is identified as a novel circular RNA that significantly enhances the proliferation, migration, invasion, and metabolic activities of bladder cancer cells through the miR-767-3p/HIF1A pathway. This research highlights the potential of circPSMA4 as a therapeutic target in bladder cancer, suggesting that interventions targeting this axis may improve treatment outcomes.