Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation
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来源：
Nature
关键字：
CRISPR
发布时间：
2025-11-19 04:06
摘要：
Notopterygii rhizoma et radix (QH) shows significant therapeutic potential for psoriasis treatment by alleviating symptoms and modulating the PI3K/Akt/mTOR signaling pathway. This study combines experimental validation with network pharmacology to elucidate QH's multi-target pharmacological nature, highlighting its role as a promising alternative to conventional therapies. The findings suggest that QH could provide a cost-effective and safe treatment option for patients with psoriasis, warranting further clinical investigation.
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关键证据
QH significantly alleviated skin symptoms, improved pathological changes, and reduced inflammation.
This is the first study to demonstrate that QH exerts anti-psoriatic effects via modulation of the PI3K/Akt/mTOR pathway.
Network pharmacology revealed 128 common targets between QH and known psoriasis-related genes.
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AI评分总结
Notopterygii rhizoma et radix (QH) shows significant therapeutic potential for psoriasis treatment by alleviating symptoms and modulating the PI3K/Akt/mTOR signaling pathway. This study combines experimental validation with network pharmacology to elucidate QH's multi-target pharmacological nature, highlighting its role as a promising alternative to conventional therapies. The findings suggest that QH could provide a cost-effective and safe treatment option for patients with psoriasis, warranting further clinical investigation.