Insights from pharmacovigilance databases, clinical cohorts and preclinical models into VEGF(R) inhibitor-induced arthritis in cancer
8.0
来源：
Nature
关键字：
multi-omics
发布时间：
2025-11-19 08:14
摘要：
This study systematically investigates the association between VEGF(R) inhibitors and arthritis incidence in cancer patients, revealing a significant increase in risk, especially among females and those under 65 years. Utilizing data from FAERS and VigiBase, the research identifies key molecular mechanisms, including alterations in SMAD signaling and calcium channel activity, that contribute to the development of arthritis. These findings provide critical insights for improving management strategies and highlight the need for further research into targeted interventions.
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domain_focus
1.0分+1.0
business_impact
0.5分+0.5
scientific_rigor
1.5分+1.5
timeliness_innovation
1.5分+1.5
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2.5分+2.5
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1.0分+1.0
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0.5分+0.5
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0.4分+0.4
关键证据
VEGF(R) inhibitors significantly increase arthritis risk, particularly in females and patients under 65.
Transcriptomic analysis reveals altered inflammatory pathways in bone tissue after treatment.
Data from FAERS and VigiBase indicate a notable incidence of arthritis-related adverse events.
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AI评分总结
This study systematically investigates the association between VEGF(R) inhibitors and arthritis incidence in cancer patients, revealing a significant increase in risk, especially among females and those under 65 years. Utilizing data from FAERS and VigiBase, the research identifies key molecular mechanisms, including alterations in SMAD signaling and calcium channel activity, that contribute to the development of arthritis. These findings provide critical insights for improving management strategies and highlight the need for further research into targeted interventions.