Circ_0003266 suppresses bladder cancer progression by modulating the miR-503-5p/SMAD7/TGF-β signaling axis
8.5
来源：
Nature
关键字：
circRNA
发布时间：
2025-11-20 00:02
摘要：
Circ_0003266 has been identified as a tumor suppressor in bladder cancer, with its expression inversely correlated with tumor size and disease stage. The study demonstrates that circ_0003266 inhibits cancer progression by regulating the miR-503-5p/SMAD7/TGF-β signaling pathway, highlighting its potential as a therapeutic target. In vivo experiments further confirm that circ_0003266 overexpression significantly reduces tumor growth, suggesting its relevance in bladder cancer treatment strategies.
原文：
查看原文
价值分投票
评分标准
新闻价值分采用0-10分制，综合考虑新闻的真实性、重要性、时效性、影响力等多个维度。
评分越高，表示该新闻的价值越大，越值得关注。
价值维度分析
domain_focus
1.0分+1.0分
business_impact
0.5分+0.5分
scientific_rigor
1.5分+1.5分
timeliness_innovation
1.5分+1.5分
investment_perspective
2.5分+2.5分
market_value_relevance
1.0分+1.0分
team_institution_background
0.5分+0.5分
technical_barrier_competition
1.0分+1.0分
关键证据
Circ_0003266 is significantly downregulated in bladder cancer tissues and cell lines.
Overexpression of circ_0003266 inhibits bladder cancer cell proliferation and migration.
Circ_0003266 modulates the miR-503-5p/SMAD7/TGF-β signaling axis.
真实性检查
否
AI评分总结
Circ_0003266 has been identified as a tumor suppressor in bladder cancer, with its expression inversely correlated with tumor size and disease stage. The study demonstrates that circ_0003266 inhibits cancer progression by regulating the miR-503-5p/SMAD7/TGF-β signaling pathway, highlighting its potential as a therapeutic target. In vivo experiments further confirm that circ_0003266 overexpression significantly reduces tumor growth, suggesting its relevance in bladder cancer treatment strategies.