Crotonoside exerts anti-colorectal cancer effects by suppressing KIF20A to regulate the cell cycle
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-20 23:43
摘要：
Crotonoside (CTS), a bioactive component from Croton, demonstrates significant anti-colorectal cancer (CRC) effects by targeting KIF20A, leading to G2/M phase cell cycle arrest. In vitro studies reveal that CTS inhibits CRC cell proliferation, invasion, and migration, while in vivo experiments confirm its efficacy in reducing tumor growth. The research underscores the potential of CTS as a therapeutic agent for CRC, addressing the urgent need for effective treatments amid rising global incidence rates.
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关键证据
CTS significantly inhibits CRC cell proliferation, invasion, and migration.
KIF20A is identified as a core target of CTS against CRC.
In vivo results show that CTS significantly inhibited CRC tumor growth.
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AI评分总结
Crotonoside (CTS), a bioactive component from Croton, demonstrates significant anti-colorectal cancer (CRC) effects by targeting KIF20A, leading to G2/M phase cell cycle arrest. In vitro studies reveal that CTS inhibits CRC cell proliferation, invasion, and migration, while in vivo experiments confirm its efficacy in reducing tumor growth. The research underscores the potential of CTS as a therapeutic agent for CRC, addressing the urgent need for effective treatments amid rising global incidence rates.