Resveratrol delays senescence of human dental pulp stem cells via activating the SIRT1-mitochondrial autophagy
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来源：
Nature
关键字：
mRNA
发布时间：
2025-11-21 23:44
摘要：
Resveratrol has been shown to delay senescence and enhance the proliferation and osteogenic differentiation of human dental pulp stem cells (hDPSCs). The study highlights the activation of SIRT1 as a crucial mechanism, which promotes mitochondrial autophagy and biogenesis, thereby improving the regenerative potential of hDPSCs. These findings suggest significant clinical implications for dental regenerative therapies, emphasizing the potential of Resveratrol in enhancing stem cell-based treatments.
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关键证据
Resveratrol treatment significantly enhanced the viability of senescent hDPSCs.
The study identified the activation of SIRT1 as a key mechanism in delaying senescence.
Resveratrol improved mitochondrial function and biogenesis in hDPSCs.
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AI评分总结
Resveratrol has been shown to delay senescence and enhance the proliferation and osteogenic differentiation of human dental pulp stem cells (hDPSCs). The study highlights the activation of SIRT1 as a crucial mechanism, which promotes mitochondrial autophagy and biogenesis, thereby improving the regenerative potential of hDPSCs. These findings suggest significant clinical implications for dental regenerative therapies, emphasizing the potential of Resveratrol in enhancing stem cell-based treatments.