MAGEA11 promotes GC proliferation, migration, and invasion through activation of E2F1 transcriptional activity
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-22 03:42
摘要：
MAGEA11, a member of the melanoma-associated antigen gene family, is found to be significantly upregulated in gastric cancer (GC) and correlates with poor prognosis. The study demonstrates that MAGEA11 promotes GC cell proliferation, migration, and invasion by activating E2F1 transcriptional activity. This research underscores the potential of MAGEA11 as a therapeutic target, particularly in improving early diagnosis and treatment strategies for gastric cancer, which remains a leading cause of cancer-related mortality.
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关键证据
MAGEA11 is an independent prognostic factor for overall survival in gastric cancer patients.
MAGEA11 promotes the proliferation, migration, and invasion of gastric cancer cells.
The study provides a theoretical foundation for future therapeutic strategies targeting MAGEA11.
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AI评分总结
MAGEA11, a member of the melanoma-associated antigen gene family, is found to be significantly upregulated in gastric cancer (GC) and correlates with poor prognosis. The study demonstrates that MAGEA11 promotes GC cell proliferation, migration, and invasion by activating E2F1 transcriptional activity. This research underscores the potential of MAGEA11 as a therapeutic target, particularly in improving early diagnosis and treatment strategies for gastric cancer, which remains a leading cause of cancer-related mortality.