HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-22 03:42
摘要：
HAT1 is identified as a lactyltransferase that regulates RPA1 lactylation, promoting DNA repair and radioresistance in lung adenocarcinoma. The study highlights HAT1's role in enhancing homologous recombination, suggesting it as a potential therapeutic target for improving radiotherapy outcomes in cancer treatment. Elevated HAT1 expression correlates with poor prognosis in patients, indicating its significance in tumor biology and treatment resistance.
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关键证据
HAT1 knockout inhibits DNA repair in lung adenocarcinoma cells, increasing radiotherapy sensitivity.
HAT1 promotes homologous recombination and radioresistance by regulating RPA1 lactylation.
HAT1 is highly expressed in lung adenocarcinoma and correlates with poor prognosis.
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AI评分总结
HAT1 is identified as a lactyltransferase that regulates RPA1 lactylation, promoting DNA repair and radioresistance in lung adenocarcinoma. The study highlights HAT1's role in enhancing homologous recombination, suggesting it as a potential therapeutic target for improving radiotherapy outcomes in cancer treatment. Elevated HAT1 expression correlates with poor prognosis in patients, indicating its significance in tumor biology and treatment resistance.