Proline-rich 15 depletion enhances Nrf2 cascade to promote osteoblast survival from oxidative injury
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-22 03:51
摘要：
PRR15 is identified as a negative regulator of the Nrf2 signaling pathway in osteoblasts, with its depletion enhancing Nrf2 activation and promoting cell survival under oxidative stress. This study demonstrates that silencing PRR15 mitigates oxidative stress and apoptosis in both murine and human osteoblasts, suggesting its potential as a therapeutic target for osteoporosis. The findings indicate that targeting PRR15 could restore bone health by enhancing the antioxidant response in osteoblasts.
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关键证据
PRR15 silencing enhances Nrf2 cascade to promote osteoblast survival.
In vivo studies show PRR15 knockdown mitigates oxidative stress and trabecular bone loss.
PRR15 interacts with BACH1 to negatively regulate Nrf2 signaling.
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AI评分总结
PRR15 is identified as a negative regulator of the Nrf2 signaling pathway in osteoblasts, with its depletion enhancing Nrf2 activation and promoting cell survival under oxidative stress. This study demonstrates that silencing PRR15 mitigates oxidative stress and apoptosis in both murine and human osteoblasts, suggesting its potential as a therapeutic target for osteoporosis. The findings indicate that targeting PRR15 could restore bone health by enhancing the antioxidant response in osteoblasts.