Esketamine prevents postoperative sleep disturbance in patients with preoperative sleep disorders: a role for oral microbiota
7.4
来源：
Nature
关键字：
AI brain science
发布时间：
2025-11-24 23:36
摘要：
Esketamine infusion during surgery significantly reduces postoperative sleep disturbance (PSD) in patients with preexisting sleep disorders, as evidenced by lower incidence rates and improved sleep quality scores. The study also highlights potential links between esketamine's effects and changes in oral microbiota, suggesting a multifaceted approach to managing PSD. This research underscores the importance of effective interventions for sleep disturbances in surgical patients.
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关键证据
Esketamine group showed a significantly lower incidence of PSD (43.1% vs. 64.6%) on postoperative day 1.
The study involved a randomized, placebo-controlled clinical trial with 130 patients.
Oral microbiota analysis revealed significant associations with clinical sleep outcomes.
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AI评分总结
Esketamine infusion during surgery significantly reduces postoperative sleep disturbance (PSD) in patients with preexisting sleep disorders, as evidenced by lower incidence rates and improved sleep quality scores. The study also highlights potential links between esketamine's effects and changes in oral microbiota, suggesting a multifaceted approach to managing PSD. This research underscores the importance of effective interventions for sleep disturbances in surgical patients.