Permethrin induces epileptic susceptibility via activation of Na+ channels and rise in glutamate
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-25 03:42
摘要：
Permethrin, a widely used insecticide, has been shown to induce epileptic susceptibility in zebrafish and mice by activating sodium channels and increasing glutamate levels. This study highlights the neurotoxic effects of permethrin, raising concerns about its safety as an insecticide and suggesting potential therapeutic targets for mitigating its adverse effects on neurological health.
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关键证据
Permethrin exposure induces dose-dependent epileptiform symptoms in zebrafish.
Study shows permethrin activates sodium ion channels, particularly Nav1.6, leading to increased glutamate levels.
Epidemiological studies link permethrin exposure to increased epilepsy prevalence.
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AI评分总结
Permethrin, a widely used insecticide, has been shown to induce epileptic susceptibility in zebrafish and mice by activating sodium channels and increasing glutamate levels. This study highlights the neurotoxic effects of permethrin, raising concerns about its safety as an insecticide and suggesting potential therapeutic targets for mitigating its adverse effects on neurological health.