The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies
5.5
来源：
Nature
关键字：
multi-omics
发布时间：
2025-11-25 04:18
摘要：
The article explores the relationship between obesity and psoriatic disease, noting that obesity affects nearly half of patients and is linked to worse treatment outcomes. It discusses mechanisms such as inflammation and biomechanical stress that contribute to this relationship. The authors advocate for integrating weight management into treatment protocols, highlighting glucagon-like peptide-1 receptor agonists as a promising therapeutic strategy that may enhance treatment efficacy.
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domain_focus
0.5
business_impact
0.5
scientific_rigor
1.5
timeliness_innovation
1.5
investment_perspective
0.0
market_value_relevance
1.0
team_institution_background
0.0
technical_barrier_competition
0.5
关键证据
Obesity is associated with lower rates of remission and poorer responses to treatment in psoriatic disease.
Weight loss can improve psoriatic disease outcomes and response to therapy.
Glucagon-like peptide-1-based therapies are effective for weight loss and may have disease-modifying effects.
真实性检查
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AI评分总结
The article explores the relationship between obesity and psoriatic disease, noting that obesity affects nearly half of patients and is linked to worse treatment outcomes. It discusses mechanisms such as inflammation and biomechanical stress that contribute to this relationship. The authors advocate for integrating weight management into treatment protocols, highlighting glucagon-like peptide-1 receptor agonists as a promising therapeutic strategy that may enhance treatment efficacy.